Adam
Adam is responsible for the day to day operation and support of the small molecule screening and characterization group, the
compound logistics group, and the automation group at EMD Serono.
His work is closely tied to the drugs used in clinics to treat diseases and often requires him to interact with colleagues
from a variety of therapeutic areas. This requires a thorough understanding of the biology intrinsic to a far-reaching spectrum
of target areas.
During his time at the company, Adam has designed novel assays for a variety of targets in order to adapt them to in-house
technology. These assays are used daily and provide a more physiologically relevant first step in identification of realistic
hits and leads -- accelerating the overall drug discovery process.
Education
Oxford University, Oxford, England. MBiochem, Biochemistry and Molecular Biology, 1st class honors (1993-1997)
Oxford University, Oxford, England. MBiochem, Biochemistry and Molecular Biology, 1st class honors (1993-1997)
National Institute of Medical Research, London, England. PhD, Physical Biochemistry (1997-2000)
Postdoctoral
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill (2001-2006)
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill (2001-2006)
Awards
Susan G Komen Breast Cancer Fellow 2004-2006
Susan G Komen Breast Cancer Fellow 2004-2006
Publications
Berzat AC, Buss JE, Chenette EJ, Chenette EJ, Weinbaum CA, Shutes A, Der CJ, Minden A, Cox AD. Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-Regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif. J Biol Chem. 2005 Sept 23;208(38):33055-33065.
Berzat AC, Buss JE, Chenette EJ, Chenette EJ, Weinbaum CA, Shutes A, Der CJ, Minden A, Cox AD. Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-Regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif. J Biol Chem. 2005 Sept 23;208(38):33055-33065.
Gibbins, JM, Briddon S, Shutes A, Van VM J, Van D WJG, Saito T, Watson SP. The p85 subunit of phosphatidylinositol 3-kinase
associates with the Fc receptor gamma-chain and linker for activator of T cells (LAT) in platelets stimulated by collagen
and convulxin. J Biol Chem. 1998; 273(51):34437-34443.
Healy KD, Hodgson L, Kim TY, Shutes A, Maddileti S, Juliano RL, Hahn KM, Harden TK, Bang YJ, Der CJ. DLC-1 suppresses non-small
cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog. 2008 May; 47(5):326-327.
Kimple RJ, Jones MB, Shutes A, Yerxa BR, Siderovski DP, Willard FS. Estabilshed and emerging rluorescence-based assays for
G-protein function: heterotrimeric G-protein alpha subunits and regulator of G-protein signaling (RGS) proteins. Comb Chem
High Throughput Screen. 2003 Jun;6(4):399-407.
Onesto C, Shutes A, Picard V, Schweighoffer F, Der CJ. Characterisation of EHT 1864, a novel small molecule inhibitor of Rac
family small GTPases. Methods Znzymol. 2008;439:111-129.
Perrin D, Frémaux C, Shutes A. Microfluidic electrophoretic mobility shift assays in drug discovery. Expert Opin Drug Discovery.
In press.
Shutes A, Berzat AC, Cox AD, Der CJ. Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase. Curr Biol. 2004
Nov 23;14(22):2052-2056.
Shutes A, Der CJ. Real-time in vitro measurement of intrinsic and Ras GAP-mediated GTP hydrolysis. Methods Enzymol. 2006;407:9-22.
Shutes A, Der CJ. Measurement of intrinsic and GAP-mediated GTP hydrolysis in real-time and in vitro. Methods Enzymol. 2008;
406:11-26.
Shutes A, Onesto C, Picard V, Leblond B, Schweighoffer F, Der CJ. Specificity and mechanism of action of EHT 1864, a novel
small molecule inhibitor of Rac family small GTPases. J Biol. Chem. 2007 Dec 7;208(49):35666-78. Epub 2007 Oct 11.
Shutes A, Phillips RA, Corrie JE, Webb MR. Role of magnesium in nucleotide exchange on the small G protein rac investigated
using novel fluorescent Guanine nucleotide analogues. Biochemistry. 2002 Mar 19;41(11):3828-3835.
PERSONAL VISION
Adam believes in a fair and equal society based on equal access to basic human rights, including freedom of expression, equality before the law, the right to food, the right to work, and the right to education. He is committed to using his skills to contribute to society in any way that he can.
Adam believes in a fair and equal society based on equal access to basic human rights, including freedom of expression, equality before the law, the right to food, the right to work, and the right to education. He is committed to using his skills to contribute to society in any way that he can.
