Friedrich Jacob Merck purchases the Angel Pharmacy (Engel Apotheke) in Darmstadt, Germany, which is still owned by the Merck family today.
The successful export business into the United States leads to the company's own establishment of the "agency for the sale of drugs and chemical products" in New York
Cesaro Serono founds the "Istitutio Farmacologico Serono" in Rome, Italy. The company specializes in the extraction and purification of natural substances.
As a consequence of WW I, Merck KGaA, Darmstadt, Germany loses its subsidiaries abroad, including Merck & Co. in the US, which had been founded in 1891. Merck & Co. becomes an independent US Company.
Serono S.A. opens offices in the United States.
Merck KGaA, Darmstadt, Germany acquires Serono S.A. This marks the largest acquisition in the history of Merck KGaA, Darmstadt, Germany. With its biopharmaceutical business known as EMD Serono in the US and Canada, Merck KGaA, Darmstadt, Germany, becomes one of the world's leading biopharmaceutical companies.